Version 5.4
Mus musculus Protein: Dsc2
Summary
InnateDB Protein IDBP-129633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dsc2
Protein Name desmocollin 2
Synonyms AW228162; Dsc2a; Dsc2b;
Species Mus musculus
Ensembl Protein ENSMUSP00000074702
InnateDB Gene IDBG-129629 (Dsc2)
Protein Structure
UniProt Annotation
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Disease Associations
Tissue Specificity In all epithelia tested and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0009267 cellular response to starvation
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
Cellular Component
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030057 desmosome
Protein Structure and Domains
PDB ID MGI:103221
InterPro IPR000233 Cadherin, cytoplasmic domain
IPR002126 Cadherin
IPR009122 Desmosomal cadherin
IPR009124 Cadherin/Desmocollin
IPR014868 Cadherin prodomain
IPR015919 Cadherin-like
PFAM PF01049
PF00028
PF08758
PRINTS PR00205
PR01818
PR01820
PIRSF
SMART SM00112
SM01055
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55292
PhosphoSite PhosphoSite-P55292
TrEMBL Q99KH1
UniProt Splice Variant
Entrez Gene 13506
UniGene Mm.473309
RefSeq XP_006525655
MGI ID
MGI Symbol Dsc2
OMIM
CCDS
HPRD
IMGT
EMBL AK078887 BC004663 CH466557 L33779 X73885
GenPept AAA79176 AAA79177 AAH04663 BAC37444 CAA52089 EDK96940

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca