Version 5.4
Mus musculus Protein: Arhgef18
Summary
InnateDB Protein IDBP-129648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef18
Protein Name rho/rac guanine nucleotide exchange factor (GEF) 18
Synonyms AI467246; D030053O22Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000004684
InnateDB Gene IDBG-129646 (Arhgef18)
Protein Structure
UniProt Annotation
Function Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Note=Colocalizes with actin stress fibers. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2142567
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9R4
PhosphoSite PhosphoSite-Q6P9R4
TrEMBL D3YWI3
UniProt Splice Variant
Entrez Gene 102098
UniGene Mm.474764
RefSeq NP_598723
MGI ID
MGI Symbol Arhgef18
OMIM
CCDS CCDS22060
HPRD
IMGT
EMBL AC169677 AK041423 AK172963 BC034512 BC060639
GenPept AAH34512 AAH60639 BAC30940 BAD32241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca