InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrfn4

Summary

InnateDB Protein

IDBP-129676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrfn4

Protein Name

leucine rich repeat and fibronectin type III domain containing 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050039

InnateDB Gene

IDBG-129674 (Lrfn4)

Protein Structure

UniProt Annotation

Function

Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery. {ECO:0000269PubMed:16828986, ECO:0000269PubMed:18585462}.

Subcellular Localization

Membrane {ECO:0000269PubMed:16828986, ECO:0000269PubMed:18227064}; Single-pass type I membrane protein {ECO:0000269PubMed:16828986, ECO:0000269PubMed:18227064}.

Disease Associations

Tissue Specificity

Expressed in brain and testis. In the brain, weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. {ECO:0000269PubMed:16828986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2385612

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM