InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rce1

Summary

InnateDB Protein

IDBP-129689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rce1

Protein Name

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

Synonyms

D19Ertd283e; D19Ertd98e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025823

InnateDB Gene

IDBG-129687 (Rce1)

Protein Structure

UniProt Annotation

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0071586	CAAX-box protein processing

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1336895

InterPro

IPR003675 CAAX amino terminal protease

PFAM

PF02517

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57791

PhosphoSite

PhosphoSite-

TrEMBL

Q99KQ3

UniProt Splice Variant

Entrez Gene

19671

UniGene

RefSeq

NP_075620

MGI ID

MGI Symbol

Rce1

OMIM

CCDS

CCDS29432

HPRD

IMGT

EMBL

AJ251644 AJ251645 AK012946 BC004060 CH466612

GenPept

AAH04060 BAB28566 CAC17013 CAC17014 EDL33057