InnateDB Protein
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IDBP-129709.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pqbp1
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Protein Name
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polyglutamine binding protein 1
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Synonyms
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npw38; PQBP-1; Sfc2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033497
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InnateDB Gene
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IDBG-129707 (Pqbp1)
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Protein Structure
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Function |
Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). {ECO:0000250, ECO:0000269PubMed:23512658}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:23512658}. Nucleus speckle {ECO:0000269PubMed:23512658}. Note=Colocalized with ATXN1 in nuclear inclusion bodies. Colocalized with POU3F2 (By similarity). Colocalizes with SRSF2 in nuclear speckles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in brain cortex and hippocampus neurons (at protein level). Expressed in brain with high level in cerebellar cortex, hippocampus and olfactory bulb. {ECO:0000269PubMed:10332029, ECO:0000269PubMed:23512658}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
34 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1859638
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InterPro |
IPR001202
WW domain
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PFAM |
PF00397
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PRINTS |
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PIRSF |
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SMART |
SM00456
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TIGRFAMs |
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Modification |
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SwissProt |
Q91VJ5
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PhosphoSite |
PhosphoSite-Q91VJ5
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TrEMBL |
A2AER9
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UniProt Splice Variant |
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Entrez Gene |
54633
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UniGene |
Mm.14616
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RefSeq |
NP_001239458
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MGI ID |
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MGI Symbol |
Pqbp1
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OMIM |
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CCDS |
CCDS29977
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HPRD |
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IMGT |
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EMBL |
AJ250406
AJ296289
AK077652
AL671978
BC009657
BC051673
BC157976
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GenPept |
AAH09657
AAH51673
AAI57977
BAC36928
CAB59205
CAC15062
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