InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timm17b

Summary

InnateDB Protein

IDBP-129729.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm17b

Protein Name

translocase of inner mitochondrial membrane 17b

Synonyms

17kDa; mTim17b; Sfc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033498

InnateDB Gene

IDBG-129727 (Timm17b)

Protein Structure

UniProt Annotation

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0015630	microtubule cytoskeleton
GO:0031305	integral component of mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:1343176

InterPro

IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
IPR005678 Mitochondrial inner membrane translocase complex, subunit Tim17

PFAM

PF02466

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0V7

PhosphoSite