InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fezf1

Summary

InnateDB Protein

IDBP-129759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fezf1

Protein Name

Fez family zinc finger 1

Synonyms

3110069A13Rik; Fez; fez-like; Zfp312-like;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031709

InnateDB Gene

IDBG-129757 (Fezf1)

Protein Structure

UniProt Annotation

Function

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors. {ECO:0000269PubMed:16540508, ECO:0000269PubMed:16971467}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0021537	telencephalon development
GO:0021772	olfactory bulb development
GO:0021797	forebrain anterior/posterior pattern specification
GO:0030900	forebrain development
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated