InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eras

Summary

InnateDB Protein

IDBP-129820.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eras

Protein Name

ES cell-expressed Ras

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033500

InnateDB Gene

IDBG-129818 (Eras)

Protein Structure

UniProt Annotation

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. {ECO:0000269PubMed:12774123}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in several undifferentiated mouse embryonic stem cell lines. {ECO:0000269PubMed:12774123}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008150	biological_process
GO:0015031	protein transport
GO:0015684	ferrous iron transport

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2665023

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF02421
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt