InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nmral1

Summary

InnateDB Protein

IDBP-129930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nmral1

Protein Name

NmrA-like family domain containing 1

Synonyms

1110025F24Rik; AI256624;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078132

InnateDB Gene

IDBG-129926 (Nmral1)

Protein Structure

UniProt Annotation

Function

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006813	potassium ion transport
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005730	nucleolus
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1915074

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003148 Regulator of K+ conductance, N-terminal
IPR008030 NmrA-like
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF01073
PF02254
PF05368
PF08659

PRINTS

PR00080

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt