InnateDB Protein
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IDBP-12995.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HDAC10
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Protein Name
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histone deacetylase 10
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000216271
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InnateDB Gene
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IDBG-12993 (HDAC10)
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Protein Structure
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Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Excluded from the nucleoli.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. High expression in liver, spleen, pancreas and kidney.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004407
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histone deacetylase activity
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GO:0005515
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protein binding
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GO:0019899
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enzyme binding
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GO:0032041
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NAD-dependent histone deacetylase activity (H3-K14 specific)
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GO:0033558
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protein deacetylase activity
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GO:0042826
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histone deacetylase binding
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GO:0046969
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NAD-dependent histone deacetylase activity (H3-K9 specific)
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GO:0046970
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NAD-dependent histone deacetylase activity (H4-K16 specific)
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GO:0097372
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NAD-dependent histone deacetylase activity (H3-K18 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000286
Histone deacetylase superfamily
IPR023801
Histone deacetylase domain
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PFAM |
PF00850
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PRINTS |
PR01270
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q969S8
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PhosphoSite |
PhosphoSite-Q969S8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83933
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UniGene |
Hs.26593
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RefSeq |
NP_114408
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HUGO |
HGNC:18128
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OMIM |
608544
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CCDS |
CCDS14088
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HPRD |
09407
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IMGT |
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EMBL |
AF393962
AF407272
AF407273
AF426160
AL022328
AL512711
AY450395
BC125083
CR456465
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GenPept |
AAI25084
AAK84023
AAK92205
AAK92206
AAL30513
AAS48345
CAC21653
CAG30351
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