InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gata1

Summary

InnateDB Protein

IDBP-129967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata1

Protein Name

GATA binding protein 1

Synonyms

eryf1; Gata-1; Gf-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033502

InnateDB Gene

IDBG-129965 (Gata1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. {ECO:0000269PubMed:15173587, ECO:0000269PubMed:16888089, ECO:0000269PubMed:2276623, ECO:0000269PubMed:8206977, ECO:0000269PubMed:8524811}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16888089}.

Disease Associations

Tissue Specificity

Erythrocytes. Expressed (at protein level) in liver. {ECO:0000269PubMed:2725678, ECO:0000269PubMed:8524811}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	38 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001158	enhancer sequence-specific DNA binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010559	regulation of glycoprotein biosynthetic process
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030220	platelet formation
GO:0030221	basophil differentiation
GO:0030222	eosinophil differentiation
GO:0030502	negative regulation of bone mineralization
GO:0033690	positive regulation of osteoblast proliferation
GO:0035162	embryonic hemopoiesis
GO:0035854	eosinophil fate commitment
GO:0043066	negative regulation of apoptotic process
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048821	erythrocyte development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527	platelet aggregation
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0097028	dendritic cell differentiation
GO:0097067	cellular response to thyroid hormone stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand