InnateDB Protein
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IDBP-129999.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Golph3
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Protein Name
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golgi phosphoprotein 3
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Synonyms
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4733401N08Rik; 5730410D03Rik; AW413496;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000057375
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InnateDB Gene
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IDBG-129997 (Golph3)
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Protein Structure
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Function |
Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform 2: Golgi apparatus.Golgi apparatus, Golgi stack membrane {ECO:0000269PubMed:17629635}; Peripheral membrane protein {ECO:0000269PubMed:17629635}; Cytoplasmic side {ECO:0000269PubMed:17629635}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:17629635}; Peripheral membrane protein {ECO:0000269PubMed:17629635}; Cytoplasmic side {ECO:0000269PubMed:17629635}. Mitochondrion intermembrane space {ECO:0000269PubMed:17629635}. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate- binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested including brain, heart, kidney, liver, lung, salivary gland, skeletal muscle, small intestine, spleen, stomach, skin and testis (at protein level). {ECO:0000269PubMed:23345592}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913879
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InterPro |
IPR008628
Golgi phosphoprotein 3
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PFAM |
PF05719
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CRA5
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PhosphoSite |
PhosphoSite-Q9CRA5
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TrEMBL |
Q3UWP6
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UniProt Splice Variant |
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Entrez Gene |
66629
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UniGene |
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RefSeq |
NP_079949
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MGI ID |
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MGI Symbol |
Golph3
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OMIM |
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CCDS |
CCDS27389
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HPRD |
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IMGT |
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EMBL |
AB271918
AK005996
AK014644
AK015543
AK136194
BC003961
BC051035
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GenPept |
AAH03961
AAH51035
BAB24357
BAB29486
BAB29889
BAE22868
BAF64720
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