InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camsap3

Summary

InnateDB Protein

IDBP-130023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camsap3

Protein Name

calmodulin regulated spectrin-associated protein family, member 3

Synonyms

2310057J16Rik; Kiaa1543; Nezha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058958

InnateDB Gene

IDBG-130021 (Camsap3)

Protein Structure

UniProt Annotation

Function

Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes. {ECO:0000269PubMed:23169647}.

Subcellular Localization

Cell junction, adherens junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes. Localizes along zonula adherens only at mature cell- cell contacts (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0051011	microtubule minus-end binding

Biological Process

GO:0010923	negative regulation of phosphatase activity
GO:0033043	regulation of organelle organization
GO:0034453	microtubule anchoring
GO:0045218	zonula adherens maintenance
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005915	zonula adherens
GO:0036449	microtubule minus-end

Protein Structure and Domains

PDB ID

MGI:1916947

InterPro

IPR001715 Calponin homology domain
IPR008946 Nuclear hormone receptor, ligand-binding
IPR011033 PRC-barrel-like
IPR014797 CKK domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF08683
PF11971

PRINTS

PIRSF

SMART

SM00033
SM01051

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80VC9