InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dsg2

Summary

InnateDB Protein

IDBP-130189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dsg2

Protein Name

desmoglein 2

Synonyms

AA408168; D18Ertd293e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057096

InnateDB Gene

IDBG-130187 (Dsg2)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in epidermis, heart, brain, spleen, lung, liver skeletal muscle, kidney and testis. {ECO:0000269PubMed:12787123}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0032570	response to progesterone
GO:0060135	maternal process involved in female pregnancy
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030057	desmosome
GO:0070062	extracellular vesicular exosome