InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc26a7

Summary

InnateDB Protein

IDBP-130197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc26a7

Protein Name

solute carrier family 26, member 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041789

InnateDB Gene

IDBG-130195 (Slc26a7)

Protein Structure

UniProt Annotation

Function

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion. {ECO:0000250UniProtKB:Q8TE54, ECO:0000269PubMed:12736153, ECO:0000269PubMed:15591059, ECO:0000269PubMed:16263805}.

Subcellular Localization

Basolateral cell membrane; Multi-pass membrane protein {ECO:0000269PubMed:12736153, ECO:0000269PubMed:16263805, ECO:0000269PubMed:16524946}. Recycling endosome membrane; Multi-pass membrane protein {ECO:0000269PubMed:12736153, ECO:0000269PubMed:16263805, ECO:0000269PubMed:16524946}. Note=Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000250UniProtKB:Q8TE54, ECO:0000269PubMed:12736153, ECO:0000269PubMed:16263805, ECO:0000269PubMed:16524946}.

Disease Associations

Tissue Specificity

Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts. {ECO:0000269PubMed:12736153, ECO:0000269PubMed:16263805, ECO:0000269PubMed:16524946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005253	anion channel activity
GO:0005254	chloride channel activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0019531	oxalate transmembrane transporter activity

Biological Process

GO:0001696	gastric acid secretion
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0019532	oxalate transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0055038	recycling endosome membrane