Version 5.4
Mus musculus Protein: Tbc1d25
Summary
InnateDB Protein IDBP-130241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbc1d25
Protein Name TBC1 domain family, member 25
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047838
InnateDB Gene IDBG-130239 (Tbc1d25)
Protein Structure
UniProt Annotation
Function Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0006914 autophagy
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:1901096 regulation of autophagic vacuole maturation
Cellular Component
GO:0005776 autophagic vacuole
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:2444862
InterPro IPR000195 Rab-GTPase-TBC domain
PFAM PF00566
PRINTS
PIRSF
SMART SM00164
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1A5B6
PhosphoSite PhosphoSite-A1A5B6
TrEMBL
UniProt Splice Variant
Entrez Gene 209815
UniGene Mm.122963
RefSeq NP_766066
MGI ID
MGI Symbol Tbc1d25
OMIM
CCDS CCDS29988
HPRD
IMGT
EMBL AK040932 AK078145 AL663032 BC128566
GenPept AAI28567 BAC30751 BAC37146 CAM19502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca