InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ero1lb

Summary

InnateDB Protein

IDBP-130300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ero1lb

Protein Name

ERO1-like beta (S. cerevisiae)

Synonyms

1300013B24Rik; 1700065B09Rik; AI447560; ero1-beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071864

InnateDB Gene

IDBG-130298 (Ero1lb)

Protein Structure

UniProt Annotation

Function

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo. {ECO:0000250, ECO:0000269PubMed:20308425}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=The association with ERP44 may be essential for its retention in the endoplasmic reticulum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in stomach and pancreas (mostly in the islets of Langerhans) (at protein level). {ECO:0000269PubMed:16012172, ECO:0000269PubMed:20308425}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Biological Process

GO:0019471	4-hydroxyproline metabolic process
GO:0022417	protein maturation by protein folding
GO:0030070	insulin processing
GO:0030198	extracellular matrix organization
GO:0042593	glucose homeostasis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process