Version 5.4
Mus musculus Protein: Retn
Summary
InnateDB Protein IDBP-130352.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Retn
Protein Name resistin
Synonyms ADSF; Fizz3; Rstn; Xcp4;
Species Mus musculus
Ensembl Protein ENSMUSP00000012849
InnateDB Gene IDBG-130350 (Retn)
Protein Structure
UniProt Annotation
Function Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in white but not brown adipose tissue in a variety of organs.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 1 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0007568 aging
GO:0009612 response to mechanical stimulus
GO:0010714 positive regulation of collagen metabolic process
GO:0014911 positive regulation of smooth muscle cell migration
GO:0032868 response to insulin
GO:0045444 fat cell differentiation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050806 positive regulation of synaptic transmission
GO:2000252 negative regulation of feeding behavior
GO:2000872 positive regulation of progesterone secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1888506
InterPro IPR009714 Resistin
PFAM PF06954
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99P87
PhosphoSite PhosphoSite-
TrEMBL Q5BMX4
UniProt Splice Variant
Entrez Gene 57264
UniGene Mm.486777
RefSeq NP_001191888
MGI ID 1RGX
MGI Symbol Retn
OMIM
CCDS CCDS22068
HPRD
IMGT
EMBL AF290870 AF323080 AF480491 AF510100 AK131613 AY928772 BC051196 CH466566
GenPept AAG59823 AAH51196 AAK83102 AAL85415 AAM46862 AAX33263 BAE20720 EDL21942 EDL21943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca