Version 5.4
Mus musculus Protein: Prl2c3
Summary
InnateDB Protein IDBP-130390.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prl2c3
Protein Name prolactin family 2, subfamily c, member 3
Synonyms MRP-2; MRP-3; MRP-3; mrp/plf3; mrp/plf3; Mrpplf3; Mrpplf3; PLF-2; PLF-3; PLF-3; Plf2; Prl2c4;
Species Mus musculus
Ensembl Protein ENSMUSP00000097393
InnateDB Gene IDBG-130386 (Prl2c3)
Protein Structure
UniProt Annotation
Function May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells. {ECO:0000269PubMed:11316781, ECO:0000269PubMed:16876275}.
Subcellular Localization Secreted {ECO:0000269PubMed:16876275}. Endoplasmic reticulum {ECO:0000269PubMed:16876275}.
Disease Associations
Tissue Specificity Expressed in placenta and hair follicles, with highest expression levels detected in the outer root sheath and no expression detected in bulb (at protein level). Expressed in placenta, skin wounds, keratinocytes and weakly in embryonic fibroblasts. Expressed in brain, cerebellum and in Neuro-2a cell line (PubMed:16876275). Not detected in liver, kidney, ovary, pituitary gland and brain (PubMed:3859868). {ECO:0000269PubMed:11316781, ECO:0000269PubMed:16876275, ECO:0000269PubMed:3859868}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0008083 growth factor activity
Biological Process
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:1341833
InterPro IPR001400 Somatotropin hormone
IPR009079 Four-helical cytokine-like, core
PFAM PF00103
PRINTS PR00836
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04768
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 26421
UniGene
RefSeq NP_036084
MGI ID
MGI Symbol Prl2c3
OMIM
CCDS CCDS36595
HPRD
IMGT
EMBL AK145995 AK164068 BC058816 BC064772 BC100299 BC132078 BC132080 K03235 U05747 X16009 X16010 X16011 X16012 X16013
GenPept AAA39945 AAB60482 AAH58816 AAH64772 AAI00300 AAI32079 AAI32081 BAE26816 BAE37612 CAA34146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca