Version 5.4
Mus musculus Protein: Npas4
Summary
InnateDB Protein IDBP-130523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npas4
Protein Name neuronal PAS domain protein 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062992
InnateDB Gene IDBG-130521 (Npas4)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene. {ECO:0000269PubMed:14701734, ECO:0000269PubMed:15363889}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:15363889}.
Disease Associations
Tissue Specificity Brain. Expressed in the limbic system and olfactory bulb. {ECO:0000269PubMed:14701734, ECO:0000269PubMed:15363889}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007165 signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:2664186
InterPro IPR000014 PAS domain
IPR013655 PAS fold-3
PFAM PF13188
PF13426
PF08447
PRINTS
PIRSF
SMART SM00091
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGD7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 225872
UniGene
RefSeq NP_705781
MGI ID
MGI Symbol Npas4
OMIM
CCDS CCDS29445
HPRD
IMGT
EMBL AB049835 AB054577 AK032607 AY730724
GenPept AAV28629 BAC19831 BAC53755 BAE20480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca