Version 5.4
Mus musculus Protein: Cd209a
Summary
InnateDB Protein IDBP-130588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd209a
Protein Name CD209a antigen
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000012847
InnateDB Gene IDBG-130586 (Cd209a)
Protein Structure
UniProt Annotation
Function Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in dendritic cells. Detected at very low levels in lung, spleen, lymph nodes and bone marrow. {ECO:0000269PubMed:11581173, ECO:0000269PubMed:11684292}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2157942
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91ZX1
PhosphoSite PhosphoSite-Q91ZX1
TrEMBL Q2TA59
UniProt Splice Variant
Entrez Gene 170786
UniGene Mm.32510
RefSeq NP_573501
MGI ID
MGI Symbol Cd209a
OMIM
CCDS CCDS22073
HPRD
IMGT
EMBL AF373408 AF374470 AK054139 AK171639 AY049062 BC111095
GenPept AAI11096 AAK85825 AAL13234 AAL27539 BAC35667 BAE42579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca