InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mep1b

Summary

InnateDB Protein

IDBP-130617.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mep1b

Protein Name

meprin 1 beta

Synonyms

Mep-1b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080866

InnateDB Gene

IDBG-130615 (Mep1b)

Protein Structure

UniProt Annotation

Function

Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in kidney, intestinal brush borders, and salivary ducts. Isoform 2 has been found in carcinoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0006954	inflammatory response

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96964

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001506 Peptidase M12A, astacin
IPR002083 MATH
IPR006026 Peptidase, metallopeptidase
IPR008294 Meprin alpha/beta subunit
IPR008974 TRAF-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF01400
PF00917

PRINTS

PR00020
PR00480

PIRSF

PIRSF001196

SMART

SM00181
SM00137
SM00061
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References