InnateDB Protein
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IDBP-130629.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Usp1
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Protein Name
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ubiquitin specific peptidase 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000088917
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InnateDB Gene
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IDBG-165640 (Usp1)
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Protein Structure
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Function |
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250UniProtKB:O94782}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004221
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ubiquitin thiolesterase activity
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GO:0004843
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ubiquitin-specific protease activity
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GO:0036459
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ubiquitinyl hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2385198
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InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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PFAM |
PF00443
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BJQ2
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PhosphoSite |
PhosphoSite-Q8BJQ2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
230484
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UniGene |
Mm.371692
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RefSeq |
XP_006503002
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MGI ID |
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MGI Symbol |
Usp1
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OMIM |
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CCDS |
CCDS18381
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HPRD |
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IMGT |
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EMBL |
AK080882
AL627349
BC018179
BC020007
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GenPept |
AAH18179
AAH20007
BAC38059
CAM21066
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