InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rin1

Summary

InnateDB Protein

IDBP-130660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rin1

Protein Name

Ras and Rab interactor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025818

InnateDB Gene

IDBG-130658 (Rin1)

Protein Structure

UniProt Annotation

Function

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Some amount is membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Weakly or no expressed in other tissues, except in testis, where it is expressed at intermediate level. In brain, it is mainly expressed in postnatal forebrain neurons in which it is localized in dendrites and colocalizes with Ras. {ECO:0000269PubMed:12574403}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017016	Ras GTPase binding

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007613	memory
GO:0008306	associative learning
GO:0031914	negative regulation of synaptic plasticity
GO:0043547	positive regulation of GTPase activity