InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ywhaq

Summary

InnateDB Protein

IDBP-130672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhaq

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Synonyms

2700028P07Rik; AA409740; AU021156; R74690;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100067

InnateDB Gene

IDBG-130670 (Ywhaq)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 260 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	260 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0047485	protein N-terminus binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006605	protein targeting
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0021762	substantia nigra development
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome