Version 5.4
Mus musculus Protein: Ubn1
Summary
InnateDB Protein IDBP-130708.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubn1
Protein Name ubinuclein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000061843
InnateDB Gene IDBG-130706 (Ubn1)
Protein Structure
UniProt Annotation
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cell junction, tight junction {ECO:0000269PubMed:18823282}. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis (By similarity). Colocalizes with TJP1. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in bile canaliculi in liver, in bronchiolar epithelium in lung and in tubular structures of gland ducts inside the olfactory epithelium and tongue epithelium. {ECO:0000269PubMed:18823282}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0006336 DNA replication-independent nucleosome assembly
GO:0010923 negative regulation of phosphatase activity
GO:0016568 chromatin modification
GO:0030216 keratinocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005923 tight junction
GO:0016605 PML body
Protein Structure and Domains
PDB ID MGI:1891307
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4G0F8
PhosphoSite PhosphoSite-Q4G0F8
TrEMBL
UniProt Splice Variant
Entrez Gene 170644
UniGene Mm.66356
RefSeq NP_080942
MGI ID
MGI Symbol Ubn1
OMIM
CCDS CCDS27931
HPRD
IMGT
EMBL AK019173 AK020146 AK084046 AK137727 AK147571 BC060723 BC098372 CH466521
GenPept AAH60723 AAH98372 BAB31587 BAB32010 BAC39106 BAE23479 BAE28001 EDK97277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca