InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrc4

Summary

InnateDB Protein

IDBP-130777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrc4

Protein Name

leucine rich repeat containing 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062158

InnateDB Gene

IDBG-130775 (Lrrc4)

Protein Structure

UniProt Annotation

Function

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma. {ECO:0000269PubMed:15967442, ECO:0000269PubMed:16980967, ECO:0000269PubMed:17785411}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=LRRC4 and DLG4 are interdependent for synaptic localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in brain. In the hippocampus, parietal cortex and piriform cortex expressed in proximal segments of CA1 pyramidal neurons. {ECO:0000269PubMed:15967442, ECO:0000269PubMed:17785411}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0050807	regulation of synapse organization
GO:0050808	synapse organization
GO:0097119	postsynaptic density protein 95 clustering

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse

Protein Structure and Domains

PDB ID

MGI:2182081

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855
PF07679

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99PH1