InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BNIP3L

Summary

InnateDB Protein

IDBP-13078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNIP3L

Protein Name

BCL2/adenovirus E1B 19kDa interacting protein 3-like

Synonyms

BNIP3a; NIX;

Species

Homo sapiens

Ensembl Protein

ENSP00000370003

InnateDB Gene

IDBG-13074 (BNIP3L)

Protein Structure

UniProt Annotation

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269PubMed:10381623, ECO:0000269PubMed:21264228}.

Subcellular Localization

Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0016032	viral process
GO:0035694	mitochondrial protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051607	defense response to virus
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane