InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRTN3

Summary

InnateDB Protein

IDBP-13086.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRTN3

Protein Name

proteinase 3

Synonyms

ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000234347

InnateDB Gene

IDBG-13084 (PRTN3)

Protein Structure

UniProt Annotation

Function

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0008284	positive regulation of cell proliferation
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050765	negative regulation of phagocytosis
GO:0097029	mature dendritic cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel

PFAM

PF00089
PF09342

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt