Version 5.4
Mus musculus Protein: Grhl1
Summary
InnateDB Protein IDBP-131006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grhl1
Protein Name grainyhead-like 1 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000082689
InnateDB Gene IDBG-131004 (Grhl1)
Protein Structure
UniProt Annotation
Function Transcription factor. May play a role in development. Binds and transactivates the EN1 promoter (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. {ECO:0000269PubMed:12175488}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:2182540
InterPro IPR007604 CP2 transcription factor
PFAM PF04516
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q921D9
PhosphoSite PhosphoSite-Q921D9
TrEMBL
UniProt Splice Variant
Entrez Gene 195733
UniGene Mm.399768
RefSeq NP_001154878
MGI ID
MGI Symbol Grhl1
OMIM
CCDS CCDS49038
HPRD
IMGT
EMBL AF411211 AF411212 AK161048 BC013080 BC037233
GenPept AAH13080 AAH37233 AAM22617 AAM22618 BAE36170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca