InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wwp1

Summary

InnateDB Protein

IDBP-131117.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwp1

Protein Name

WW domain containing E3 ubiquitin protein ligase 1

Synonyms

8030445B08Rik; AIP5; SDRP1; Tiul1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041627

InnateDB Gene

IDBG-131115 (Wwp1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT- 1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. {ECO:0000250, ECO:0000269PubMed:15003522, ECO:0000269PubMed:15735697, ECO:0000269PubMed:18724389, ECO:0000269PubMed:18806757, ECO:0000269PubMed:19561640}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15735697}. Cell membrane {ECO:0000269PubMed:15735697}; Peripheral membrane protein {ECO:0000269PubMed:15735697}. Nucleus {ECO:0000269PubMed:15735697}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0030217	T cell differentiation
GO:0030324	lung development
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated