InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calu

Summary

InnateDB Protein

IDBP-131140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calu

Protein Name

calumenin

Synonyms

9530075H20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031779

InnateDB Gene

IDBG-131138 (Calu)

Protein Structure

UniProt Annotation

Function

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen. Melanosome {ECO:0000250}. Sarcoplasmic reticulum lumen {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0033018	sarcoplasmic reticulum lumen
GO:0042470	melanosome