Mus musculus Protein: Lrrc8e | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-131148.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Lrrc8e | ||||||
Protein Name | leucine rich repeat containing 8 family, member E | ||||||
Synonyms | 1810049O03Rik; C87354; | ||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000052055 | ||||||
InnateDB Gene | IDBG-131146 (Lrrc8e) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}. | ||||||
Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||
Disease Associations | |||||||
Tissue Specificity | |||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:1919517 | ||||||
InterPro |
IPR001611
Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype IPR021040 Leucine-rich repeat-containing protein 8, N-terminal |
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PFAM |
PF00560
PF13504 PF13855 PF12534 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00369
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q66JT1 | ||||||
PhosphoSite | PhosphoSite-Q66JT1 | ||||||
TrEMBL | Q9CVJ5 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 72267 | ||||||
UniGene | Mm.25479 | ||||||
RefSeq | NP_082451 | ||||||
MGI ID | |||||||
MGI Symbol | Lrrc8e | ||||||
OMIM | |||||||
CCDS | CCDS22079 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AC123029 AK007851 BC080783 CH466566 | ||||||
GenPept | AAH80783 BAB25305 EDL21975 | ||||||