InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYRK4

Summary

InnateDB Protein

IDBP-13119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYRK4

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000010132

InnateDB Gene

IDBG-13117 (DYRK4)

Protein Structure

UniProt Annotation

Function

Possible non-essential role in spermiogenesis. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17292540}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt