InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0d2

Summary

InnateDB Protein

IDBP-131203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0d2

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit D2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029900

InnateDB Gene

IDBG-131201 (Atp6v0d2)

Protein Structure

UniProt Annotation

Function

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation. {ECO:0000250, ECO:0000269PubMed:12963731, ECO:0000269PubMed:17128270}.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in the kidney. Also expressed in the lung, testis, skeletal muscle and heart. Upr- egulated during osteoclast differentiation and is most abundant in mature osteoclasts. {ECO:0000269PubMed:12527205, ECO:0000269PubMed:12963731, ECO:0000269PubMed:17128270}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome