InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dynlt3

Summary

InnateDB Protein

IDBP-131227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dynlt3

Protein Name

dynein light chain Tctex-type 3

Synonyms

2310075M16Rik; AU042796; Tcte1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033519

InnateDB Gene

IDBG-131225 (Dynlt3)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0007067	mitotic nuclear division
GO:0007346	regulation of mitotic cell cycle
GO:0008152	metabolic process

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005868	cytoplasmic dynein complex
GO:0005874	microtubule
GO:0005886	plasma membrane