Version 5.4
Mus musculus Protein: Timm44
Summary
InnateDB Protein IDBP-131328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Timm44
Protein Name translocase of inner mitochondrial membrane 44
Synonyms 0710005E20Rik; D8Ertd118e; Mimt44; Tim44;
Species Mus musculus
Ensembl Protein ENSMUSP00000003029
InnateDB Gene IDBG-131326 (Timm44)
Protein Structure
UniProt Annotation
Function Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Subcellular Localization Mitochondrion inner membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0071806 protein transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:1343262
InterPro IPR007379 Tim44-like domain
IPR017303 Mitochondrial import inner membrane translocase subunit Tim44
PFAM PF04280
PRINTS
PIRSF PIRSF037871
SMART SM00978
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35857
PhosphoSite PhosphoSite-O35857
TrEMBL Q8R3X4
UniProt Splice Variant
Entrez Gene 21856
UniGene Mm.195249
RefSeq NP_035722
MGI ID
MGI Symbol Timm44
OMIM
CCDS CCDS22083
HPRD
IMGT
EMBL BC023454 BC110677 BC117523 BC117524 CH466566 U69898
GenPept AAB97624 AAH23454 AAI10678 AAI17524 AAI17525 EDL21992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca