InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flnb

Summary

InnateDB Protein

IDBP-131378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flnb

Protein Name

filamin, beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052020

InnateDB Gene

IDBG-131376 (Flnb)

Protein Structure

UniProt Annotation

Function

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cytoplasm, cytoskeleton. Note=May localize also at actin stress fibers and within the Z-lines. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in hippocampus, cortex, cerebellar Purkinje cells and granule cell layers. {ECO:0000269PubMed:12393796}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007519

skeletal muscle tissue development

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005938	cell cortex
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome