InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ank

Summary

InnateDB Protein

IDBP-131384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ank

Protein Name

progressive ankylosis

Synonyms

ank; Ankh; D15Ertd221e; mKIAA1581;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022875

InnateDB Gene

IDBG-131382 (Ank)

Protein Structure

UniProt Annotation

Function

Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Ankh are the cause of a generalized, progressive form of arthritis. In ank mice hydroxyapatite crystals develop in articular surfaces and synovial fluid leading to joint space narrowing, cartilage erosion, and formation of bony outgrowths or osteophytes that cause fusion and joint immobility and destruction.

Tissue Specificity

Expressed in heart, brain, liver, spleen, lung, muscle, and kidney of adult animals. Strongly expressed in the developing articular cartilage of joints in the shoulder, elbow, wrist, and digits of the embryo.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0015114	phosphate ion transmembrane transporter activity
GO:0030504	inorganic diphosphate transmembrane transporter activity