InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Galnt1

Summary

InnateDB Protein

IDBP-131487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galnt1

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000430

InnateDB Gene

IDBG-131485 (Galnt1)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269PubMed:9153242}.

Subcellular Localization

Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Polypeptide N- acetylgalactosaminyltransferase 1 soluble form: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed at high level. Higher expression in kidney, heart, small intestine and cervix and to a lesser extent in all the other tissues tested. {ECO:0000269PubMed:12651884, ECO:0000269PubMed:9153242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006493	protein O-linked glycosylation
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm