InnateDB Protein
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IDBP-131543.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rp1
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Protein Name
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retinitis pigmentosa 1 (human)
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Synonyms
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Dcdc3; mG145; Orp1; Rp1h;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027032
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InnateDB Gene
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IDBG-131541 (Rp1)
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Protein Structure
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Function |
Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme. {ECO:0000269PubMed:14507858, ECO:0000269PubMed:15269252}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment. Note=Specifically localized in the connecting cilia of rod and cone photoreceptors.
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Disease Associations |
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Tissue Specificity |
Expressed in the cell bodies and inner segments of photoreceptors. Not found in liver, spleen, kidney, brain, thymus, muscle, heart, lung and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1341105
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InterPro |
IPR003533
Doublecortin domain
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PFAM |
PF03607
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PRINTS |
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PIRSF |
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SMART |
SM00537
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TIGRFAMs |
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Modification |
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SwissProt |
P56716
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PhosphoSite |
PhosphoSite-P56716
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TrEMBL |
Q9QZY0
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UniProt Splice Variant |
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Entrez Gene |
19888
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UniGene |
Mm.408336
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RefSeq |
NP_035413
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MGI ID |
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MGI Symbol |
Rp1
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OMIM |
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CCDS |
CCDS14804
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HPRD |
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IMGT |
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EMBL |
AF146593
AF155141
AF291754
AK044413
AK044612
BC120927
BC120928
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GenPept |
AAD42089
AAD46770
AAI20928
AAI20929
AAM17919
BAC31909
BAC32003
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