InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp1

Summary

InnateDB Protein

IDBP-131592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp1

Protein Name

caspase 1

Synonyms

ICE; Il1bc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027015

InnateDB Gene

IDBG-131590 (Casp1)

Protein Structure

UniProt Annotation

Function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0016485	protein processing
GO:0032496	response to lipopolysaccharide
GO:0032611	interleukin-1 beta production
GO:0033198	response to ATP
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0051882	mitochondrial depolarization
GO:0060081	membrane hyperpolarization
GO:0070269	pyroptosis
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0097194	execution phase of apoptosis
GO:0097300	programmed necrotic cell death

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0072557	IPAF inflammasome complex
GO:0072558	NLRP1 inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Protein Structure and Domains

PDB ID

MGI:96544

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References