InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shcbp1

Summary

InnateDB Protein

IDBP-131632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shcbp1

Protein Name

Shc SH2-domain binding protein 1

Synonyms

mPAL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022945

InnateDB Gene

IDBG-131630 (Shcbp1)

Protein Structure

UniProt Annotation

Function

May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. {ECO:0000269PubMed:10086341, ECO:0000269PubMed:22508726}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in spleen, lung and heart with higher expression in testis. No expression in brain, liver and skeletal muscle. Elevated expression in actively cycling cells. {ECO:0000269PubMed:10086341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0008543	fibroblast growth factor receptor signaling pathway
GO:2000177	regulation of neural precursor cell proliferation

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1338802

InterPro

IPR006626 Parallel beta-helix repeat
IPR011050 Pectin lyase fold/virulence factor
IPR011459 Domain of unknown function DUF1565

PFAM

PF07602

PRINTS

PIRSF

SMART

SM00710

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z179

PhosphoSite

PhosphoSite-Q9Z179

TrEMBL

UniProt Splice Variant

Entrez Gene

20419

UniGene

RefSeq

NP_035499

MGI ID

MGI Symbol

Shcbp1

OMIM

CCDS

CCDS22088

HPRD

IMGT

EMBL

AF017152 AK144966 AK149580 BC070455

GenPept

AAD01613 AAH70455 BAE26159 BAE28972