InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pxk

Summary

InnateDB Protein

IDBP-131644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pxk

Protein Name

PX domain containing serine/threonine kinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035265

InnateDB Gene

IDBG-131642 (Pxk)

Protein Structure

UniProt Annotation

Function

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. {ECO:0000250UniProtKB:Q7Z7A4, ECO:0000269PubMed:16135750}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16135750}. Cell membrane {ECO:0000269PubMed:16135750}; Peripheral membrane protein {ECO:0000269PubMed:16135750}. Note=Also associates with the plasma membrane.

Disease Associations

Tissue Specificity

Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2. {ECO:0000269PubMed:16135750}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0032780	negative regulation of ATPase activity
GO:0043271	negative regulation of ion transport
GO:0050804	regulation of synaptic transmission

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1289230

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001683 Phox homologous domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003124 WH2 domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714
PF00787
PF02205

PRINTS

PR00109

PIRSF

SMART

SM00312
SM00220
SM00246

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt