Version 5.4
Mus musculus Protein: Lypla1
Summary
InnateDB Protein IDBP-131647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lypla1
Protein Name lysophospholipase 1
Synonyms Pla1a;
Species Mus musculus
Ensembl Protein ENSMUSP00000027036
InnateDB Gene IDBG-131645 (Lypla1)
Protein Structure
UniProt Annotation
Function Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002084 protein depalmitoylation
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
GO:0042997 negative regulation of Golgi to plasma membrane protein transport
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1344588
InterPro IPR003140 Phospholipase/carboxylesterase/thioesterase
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02230
PF07859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97823
PhosphoSite PhosphoSite-P97823
TrEMBL J3QQ63
UniProt Splice Variant
Entrez Gene 18777
UniGene Mm.396313
RefSeq NP_032892
MGI ID
MGI Symbol Lypla1
OMIM
CCDS CCDS14806
HPRD
IMGT
EMBL AC102311 AK002674 AK050549 AK146874 AK167231 BC013536 BC052848 U89352
GenPept AAB48627 AAH13536 AAH52848 BAB22276 BAC34318 BAE27497 BAE39355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca