InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc39a6

Summary

InnateDB Protein

IDBP-131677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc39a6

Protein Name

solute carrier family 39 (metal ion transporter), member 6

Synonyms

Ermelin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064667

InnateDB Gene

IDBG-131675 (Slc39a6)

Protein Structure

UniProt Annotation

Function

May act as a zinc-influx transporter. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Found in the endoplasmic reticulum when overexpressed. {ECO:0000269PubMed:11891044}.

Disease Associations

Tissue Specificity

Highly expressed in the brain and testis. In the brain strongly expressed in the CA1 and CA3 regions, Purkinje cells in cerebellum and dentate gyrus in hippocampus. In testis found in spermatids or mature sperms in the central areas of seminiferous tubules. {ECO:0000269PubMed:11891044}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0046873	metal ion transmembrane transporter activity

Biological Process

GO:0006882	cellular zinc ion homeostasis
GO:0030001	metal ion transport
GO:0055085	transmembrane transport
GO:0071577	zinc ion transmembrane transport
GO:0071578	zinc ion transmembrane import

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031258	lamellipodium membrane