InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cmpk2

Summary

InnateDB Protein

IDBP-131703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cmpk2

Protein Name

cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Synonyms

1200004E04Rik; TDKI; Tyki;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020969

InnateDB Gene

IDBG-131701 (Cmpk2)

Protein Structure

UniProt Annotation

Function

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004127	cytidylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0004798	thymidylate kinase activity
GO:0005524	ATP binding
GO:0009041	uridylate kinase activity
GO:0033862	UMP kinase activity

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006227	dUDP biosynthetic process
GO:0006233	dTDP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0071222	cellular response to lipopolysaccharide