InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v1h

Summary

InnateDB Protein

IDBP-131746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v1h

Protein Name

ATPase, H+ transporting, lysosomal V1 subunit H

Synonyms

0710001F19Rik; AU022349; CGI-11; SFD; SFDalpha; SFDbeta; VMA13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040756

InnateDB Gene

IDBG-131744 (Atp6v1h)

Protein Structure

UniProt Annotation

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0046961	proton-transporting ATPase activity, rotational mechanism