Version 5.4
Mus musculus Protein: Kcp
Summary
InnateDB Protein IDBP-131758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcp
Protein Name kielin/chordin-like protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000077251
InnateDB Gene IDBG-131756 (Kcp)
Protein Structure
UniProt Annotation
Function Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways. {ECO:0000269PubMed:15793581}.
Subcellular Localization Secreted {ECO:0000269PubMed:15793581}.
Disease Associations
Tissue Specificity Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines. {ECO:0000269PubMed:15793581}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0030513 positive regulation of BMP signaling pathway
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:2141640
InterPro IPR001007 von Willebrand factor, type C
IPR001846 von Willebrand factor, type D domain
IPR006552 VWC out
PFAM PF00093
PF00094
PRINTS
PIRSF
SMART SM00214
SM00216
SM00215
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3U492
PhosphoSite PhosphoSite-Q3U492
TrEMBL
UniProt Splice Variant
Entrez Gene 333088
UniGene Mm.332961
RefSeq XP_006505196
MGI ID
MGI Symbol Kcp
OMIM
CCDS
HPRD
IMGT
EMBL AC079276 AK154369 AY884211
GenPept AAX77677 BAE32541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca