InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Efnb2

Summary

InnateDB Protein

IDBP-131777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efnb2

Protein Name

ephrin B2

Synonyms

ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001319

InnateDB Gene

IDBG-131775 (Efnb2)

Protein Structure

UniProt Annotation

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269PubMed:10704386}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on lateral floor plate cells, specifically on commissural axon segments that have passed through the floor plate. Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001945	lymph vessel development
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016477	cell migration
GO:0048013	ephrin receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050920	regulation of chemotaxis
GO:2000727	positive regulation of cardiac muscle cell differentiation